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Search: db:Swepub > Journal article > Lindholm B > Yenicesu M

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  • Caglar, K, et al. (author)
  • Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease
  • 2008
  • In: Nephron. Clinical practice. - : S. Karger AG. - 1660-2110. ; 108:3, s. C233-C240
  • Journal article (peer-reviewed)abstract
    • <i>Background:</i> Defective endothelial function, an initial step in the development of atherosclerotic plaque, is prevalent in moderate to advanced chronic kidney disease (CKD). In this study, the investigators hypothesized that fetuin-A, a calcification inhibitor, is a novel risk factor for the development of endothelial dysfunction in patients. <i>Methods:</i> 198 nondiabetic patients with a mean age of 44.0 ± 12.4 years and with different stages of CKD were studied. In addition to a detailed metabolic panel, flow-mediated dilatation assessed by high-resolution brachial ultrasonography was performed to determine endothelial dysfunction. Carotid intima-media thickness was also estimated by ultrasonography. Serum fetuin-A concentrations were determined by using a human ELISA method. <i>Results:</i> Endothelial dysfunction was observed in all stages (1–5) of CKD and worsened in parallel to the reduction in estimated glomerular filtration rate. Serum fetuin-A concentrations were also found to be decreased in all but stage 1 CKD. On multiple regression analysis, endothelial dysfunction was independently associated with fetuin-A (β = 0.745, p < 0.001) and intact parathyroid hormone concentrations (β = –0.216, p < 0.001). <i>Conclusion:</i> These data in a selected cohort of CKD patients indicate that fetuin-A may be one of the contributing factors for the development of endothelial dysfunction in CKD patients.
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  • Result 1-9 of 9
Type of publication
Type of content
peer-reviewed (9)
Author/Editor
Stenvinkel, P (9)
Carrero, JJ (8)
Yilmaz, MI (8)
Saglam, M (8)
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Caglar, K (7)
Sonmez, A (7)
Eyileten, T (7)
Qureshi, AR (6)
Axelsson, J (6)
Oguz, Y (6)
Vural, A (6)
Cakir, E (5)
Heimburger, O (2)
Barany, P (2)
Alvestrand, A (1)
Suliman, ME (1)
Ikizler, TA (1)
Kilic, S (1)
Tasar, M (1)
Acikel, C (1)
Ozgurtas, T (1)
Yimaz, MI (1)
Ipcioglu, OM (1)
Tong, ML (1)
Celik, T (1)
Kirkpantur, A (1)
Aslan, I (1)
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University
Karolinska Institutet (9)
Language
English (9)

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